A high performance glucose biosensor enhanced via nanosized SiO"2 [An article from: Analytica Chimica Acta] Review
A high performance glucose biosensor enhanced via nanosized SiO"2 [An article from: Analytica Chimica Acta] Feature
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
A series of monodispersed nano-SiO"2 film enhanced glucose biosensors with different thickness were fabricated by using dip-coating method. The suitable thickness of nanosized SiO"2 film provided optimal environment for glucose oxidase to retain its bioactivity. A key factor to fabricate high sensitivity glucose biosensor was to enlarge the enzyme loading on the surface. The high surface area of the small nanosized SiO"2 particles in the thick film increased the surface enzyme loading, resulting in the high performance of the biosensor. But if the film is too thick, the performance of the sensor would decrease because the mass transfer of glucose and H"2O"2 became difficulty. The electrochemical response of glucose with the 800nm SiO"2-biosensor revealed a linear behavior in the range of 0.005-2.5mM glucose in pH 7.2 phosphate buffer solution. Such a glucose biosensor held its sensitivity as high as 71.1@mAmM^-^1cm^-^2 and its detection limit as low as 0.3@mM. The good sensor-to-sensor reproducibility also indicates the simpleness and practicability of this kind of biosensor.
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